Human Interleukin-10, Wikimedia Commons
Yoon, S.I., Logsdon, N.J., Sheikh, F., Donnelly, R.P., Walter, M.R. Conformational changes mediate IL-10R2 binding to IL-10 and assembly of the signaling complex. J.Biol.Chem. , 2006
an anti-inflammatory human cytokine (the bad guys that make you feel sick when you catch a virus or your immune system is active) I was under the impression that cytokines are always bad guys in excess, but as with everything in the human body, it's all about a balance. Fascinating character, can't explain it better than wikipedia so I suggest you check there if you're interested.
Looking at it isn't gonna change your life, but for me it was nostalgic to look at the pig-tail "alpha helices" Doesn't look like there are any beta sheets going on... hummm (= __ -)
Tutoring was fun today. Slept ok. Slightly rough start but did ok and didn't feel like my mouth was going numb when I was trying to tutor today... no anxiety but I think I definitely have a 5-HTP related headache today and feel drugged, sleepy, and achy. Made it through my test but my head was hurrrrr-ting. Not a migraine or anything, I think it's definitely a side effect of the 5-HTP and all 5-HTPs little helpers (taurine, magnesium). Lunch and drinking water definitely HELPED with the headache. So adequate food and water is definitely a must while I'm on this stuff...
The things they do not take you in biology. I cannot tell you the degree of how exothermic or endothermic the binding of a protein to a cell receptor site is (I don't really care) but I'm definitely getting fluent at reading articles... and kind of feel a nostalgic sort of pangs when I read articles (such as the one linked below) and I see little protein model depictions... nostalgic pangs for biology class... it's too bad they make it so damn hard for people to succeed. And the immense frustration I feel that that is what science must be about... who cares if you can understand the bigger picture, if you are interested in specific research questions that are relevant to the times and needs of society... why should potential pioneers be turned away and disenfranchised because they do not fit into the painful molds that university's create to measure success? I've learned more in outside reading than I have ever learned in a lecture hall. Perhaps the base of my difficulty focusing on the subjects is my disinterest in what they force me to learn. And it's not even disinterest but I think the pressure and inflated importance placed on test performance... I can try to understand the abstract concepts or I can drill my faculties down to naught studying what feel like relative frivolities that show up on tests. Absolutely maddening to do 67 work when you feel like you have understanding.
Very interesting article... interesting that historically anti-depressant herbs... and even modern remedies... act as anti-inflammatories in the body. I do believe in the neuro-immune research that is coming out that is showing a lot of how vaccines do damage is getting somewhere. And don't even get me started on the environmental-endocrine hypothesis. And excitotoxins. I'll try to avoid falling into putting stock in conspiracy theories... (neither of the above mentioned are [conspiracy theories], although they can certainly lead one to think they are) but many do comethe notion (in error) that progress is positive and that the latest and greatest can't possibly pose to mind. I like to think the only evil thing at play here is man's despicable love of money...
Again I was actually able to tell something of a story in my blog today. It must mean that something is getting better.
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